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ey0015.5-12 | Klotho in the control of osteocyte activity | ESPEYB15

5.12 Klotho expression in osteocytes regulates bone metabolism and controls bone formation

H Komaba , J Kaludjerovic , DZ Hu , K Nagano , K Amano , N Ide , T Sato , MJ Densmore , JI Hanai , H Olauson , T Bellido , TE Larsson , R Baron , B Lanske

To read the full abstract: Kidney Int 2017;92:599-611Klotho was originally identified as a senescence-related protein because mice carrying hypomorphic Klotho alleles (kl/kl) develop premature aging with low bone turnover and osteoporosis. Primary function of Klotho is to form a specific receptor complex with fibroblast growth factor (FGF) receptor 1 (FGFR1) through which it mediates the bio...

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ey0016.15-15 | (1) | ESPEYB16

15.15. Irisin mediates effects on bone and fat via [alpha]V integrin receptors

H Kim , CD Wrann , M Jedrychowski , S Vidoni , Y Kitase , K Nagano , C Zhou , J Chou , VA Parkman , SJ Novick , TS Strutzenberg , BD Pascal , PT Le , DJ Brooks , AM Roche , KK Gerber , L Mattheis , W Chen , H Tu , ML Bouxsein , PR Griffin , R Baron , CJ Rosen , LF Bonewald , BM Spiegelman

To read the full abstract: Cell. 2018 Dec 13;175(7):17561768.e17.Irisin, a cytokine secreted by muscle during exercise, effects bone resorption and the differentiation of preadipocytes into thermogenic brown fat cells by displacing tethers between the cell and extracellular matrix molecules. Physical activity can reverse age-dependent decline in skeletal muscle, preventing osteopor...

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ESPE Yearbook of Paediatric Endocrinology

5.12 Klotho expression in osteocytes regulates bone metabolism and controls bone formation

15.15. Irisin mediates effects on bone and fat via [alpha]V integrin receptors

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